Prediction of Sinensetin from Kumis Kucing (Orthosiphon aristatus) as Aspulvinone Dimethylallyltransferase Inhibitor for Anticancer Agent
DOI:
https://doi.org/10.64123/mijm.v1.i1.3Keywords:
Sinensetin, Orthosiphon aristatus, Aspulvinone Dimethylallyltransferase, Anticancer, In Silico PredictioAbstract
Sinensetin, a polymethoxylated flavone found in Orthosiphon aristatus (commonly known as Kumis Kucing), was evaluated in silico for its potential inhibitory activity against Aspulvinone Dimethylallyltransferase, an enzyme implicated in cancer-related biosynthetic pathways. The SMILES structure of sinensetin was retrieved from PubChem and analyzed using the PASS online prediction tool (www.way2drug.com). The results showed a high probability of activity (Pa = 0.865) and a very low probability of inactivity (Pi = 0.016), indicating that sinensetin is likely to act as a potent inhibitor of the enzyme. These findings suggest that sinensetin could be a promising anticancer agent candidate by targeting Aspulvinone Dimethylallyltransferase. Further studies are recommended to validate this prediction through molecular docking and biological assays.
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Copyright (c) 2025 Fendy Prasetyawan, Chandra Arifin, Widhi Astutik, Eka Hayati Rohmah, Mujtahid Bin Abd Kadir, M Wahyu Ariawan, Yogi Bhakti Marhenta, Ratna Mildawati, Yuneka Saristiana, Abd Rofiq (Author)
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